Exposición a pantallas de niñas, niños y adolescentes: recomendaciones, límites y controversias en el marco del distanciamiento social obligatorio: un estudio cualitativo / Child and Teenage Screen Exposure: Recommendations, Limits,and Controversies in the Context of Enforced Social Distancing: a Qualitative Study

Introducción: la utilización de pantallas durante la niñez y la preocupación por su potencial daño aumentaron en los últimos años. La recomendación de no superar dos horas diarias de uso resultó controvertida durante la pandemia por COVID-19. El objetivo principal de esta investigación fue explorar las opiniones y actitudes de los profesionales con respecto al uso de pantallas y comprender cómo se modificaron durante dicha pandemia. Materiales y métodos: estudio exploratorio con enfoque cualitativo y estrategia de teoría fundamentada, realizado entre 2020 y 2021.Participaron 23 profesionales (pediatras y generalistas) en cuatro grupos focales. Se realizaron lecturas del material desgrabado para interpretación del contenido. El análisis incluyó la generación de códigos que fueron agrupados en cinco ejes temáticos. Resultados: los ejes resultantes fueron: 1) temática de las pantallas en la consulta ambulatoria de niños sanos, 2) percepción sobre daños, 3) percepción sobre beneficios, 4) pantallas en épocas de ASPO (Aislamiento Social Preventivo y Obligatorio) y 5) pensamientos y acciones contradictorios sobre el uso de pantallas. Discusión: a la hora de recomendar sobre exposición a pantallas, en nuestros entrevistados predominó la intuición personal por sobre la evidencia científica disponible. Reconocieron que el contexto de ASPO visibilizó algunos beneficios asociados a la conectividad que brindan estos dispositivos. Conclusión: nuestros resultados muestran que la percepción sobre las pantallas se está volviendo cada vez más neutral en términos del balance entre sus riesgos y beneficios, conduciendo a que los profesionales sean más flexibles en sus recomendaciones al respecto. (AU)

Introduction: screen use during childhood and potential harm concerns have increased in recent years. Advice not to allow more than two hours of screen use per day was contested during the COVID-19 pandemic. The primary purpose of this research was to probe the opinions and attitudes of professionals regarding the use of screens and to understand how these changed during the pandemic. Materials and methods: this exploratory study, with a qualitative approach and theory-based strategy, was made between 2020 and 2021, and involved the participation of 23 professionals (pediatricians and general practitioners) in four focus groups. The recorded material was analyzed for content interpretation. The analysis included generating codes that were grouped into five thematic areas. Results: the resulting axes were: 1) the issue of screens in the outpatient practice of healthy children; 2) perception of harm; 3) perception of benefits; 4) screens in times of Preventive and Compulsory Social Isolation (ASPO, for its acronym in Spanish); and 5) contradictory thoughts and actions on the use of screens. Discussion: when making recommendations regarding screen exposure, the interviewees' intuition predominated over available scientific evidence. They recognized that the ASPO context highlighted some of the benefits associated with the connectivity provided by these devices. Conclusion: our results show that awareness of screen displays is becoming increasingly neutral concerning the trade-off between their risks and benefits, prompting practitioners to become more flexible in their recommendations. (AU)

Social Expectancy Increases Skin Conductance Response in Mobile Instant Messaging Users / La Expectativa Social Incrementa la Respuesta Electrodérmica en Usuarios de Mensajería Instantánea Móvil

Background: Society is witnessing two parallel phenomena: an increase in the number of mobile phone users worldwide and a growing concern about problematic smartphone use. Leading explanatory models suggest that social reward may explain some problematic smartphone use. Given that experimental evidence about the impact of social variables on problematic smartphone use is scarce, the impact of social expectancy on emotional arousal measured with skin conductance response (SCR) was analysed during instant messaging. Method: A sample of 86 undergraduate students were randomly assigned to two groups. Experimental group participants were instructed to send a social expectation-generating message to their more active contacts in their preferred social network. After experiencing a virtual reality distraction environment, participants’ SCR was measured when they were allowed to use the smartphone and when it was withdrawn. Results: Participants in the experimental group showed a higher SCR response than the control group. Peaks analysis also showed that peak amplitude was higher in experimental participants when their smartphones were used and withdrawn. Experimental participants also showed a longer half recovery time when using the smartphone. Conclusions: Social expectancy is a critical variable in understanding problematic smartphone use and it should be considered in clinical contexts.(AU)

Antecedentes: La sociedad está presenciando dos fenómenos paralelos: el incremento mundial de usuarios de teléfonos móviles y una preocupación creciente por el uso problemático de estos dispositivos. Los modelos teóricos explicativos sugieren que la recompensa social podría explicar parte del uso problemático del teléfono móvil. Dado que la evidencia experimental sobre el impacto que lo social tiene en este fenómeno es limitada, el impacto de la expectativa social sobre el arousalemocional fue analizada mientras se usó mensajería instantánea. Método: Una muestra de 86 estudiantes se asignó aleatoriamente a dos grupos. Los participantes del grupo experimental enviaron un mensaje generador de expectativa social a sus contactos más activos usando su red social preferida. Tras un periodo de distracción, a respuesta electrodérmica de la piel se midió al usar y retirar el móvil. Resultados: El grupo experimental mostró mayores niveles de arousal. El análisis de picos muestra una mayor amplitud en el grupo experimental cuando se usó y se retiró el móvil. Un tiempo de recuperación medio más largo se observó en el grupo experimental al usar el móvil. Conclusiones: La expectativa social es una variable crítica para conceptualizar el uso problemático del móvil y debería considerarse en contextos clínicos.(AU)

O significado do uso de telas entre adolescentes: causas e consequências / El significado del uso de pantallas entre adolescentes: causas y consecuencias / The signification of the use of screens among adolescents: causes and consequences

RESUMO Objetivo: compreender o significado do uso de telas atribuído pelos adolescentes. Métodos: o presente estudo foi descritivo exploratório, com abordagem qualitativa e referencial teórico-metodológico do interacionismo simbólico. Participaram adolescentes de uma escola pública mineira. Os dados foram coletados através de entrevistas e grupos focais realizados de forma online e analisados conforme a análise temática no período deagosto a dezembro de 2020. Resultados: participaram oito adolescentescom idades entre 14 e 17 anos, que cursavam o ensino médioe relataram que a tela mais usada foi o celular. Os significados atribuídos ao uso de telas estiveram relacionados à possibilidade de interação e praticidade por possibilitar a realização de várias atividades. Houve o reconhecimento que, diante do uso excessivo, é preciso ter momento distante da tela. Após a análise foram desveladas três categorias: 1. Tela é diversidade 2. Tela é interação, 3. É bom parar um pouco. Considerações finais: a pesquisa mostrou que distanciar-se das telas é difícil e que a presença de profissionais da saúde, particularmente relacionados à saúde do adolescente, pode ajudá-los a encontrar alternativas para usar as telas com redução das consequências negativas.

RESUMEN Objetivo: comprender el significado del uso de pantallas asignado por los adolescentes. Métodos: el presente estudio fue descriptivo exploratorio, con abordaje cualitativo y referencial teórico-metodológico del interaccionismo simbólico. Participaron adolescentes de una escuela pública de Minas Gerais-Brasil. Los datos fueron recolectados a través de entrevistas y grupos focales realizados en forma online y analizados conforme el análisis temático en el período de agosto a diciembre de 2020. Resultados: participaron ocho adolescentes con edades entre 14 y 17 años, que cursaban la enseñanza secundaria y relataron que la pantalla más usada fue el celular. Los significados atribuidos al uso de pantallas estuvieron relacionados a la posibilidad de interacción y practicidad por posibilitar la realización de varias actividades. Hubo el reconocimiento de que, ante el uso excesivo, es necesario tener momento alejado de la pantalla. Después del análisis surgieron tres categorías: 1. La pantalla es diversidad; 2. La pantalla es interacción; 3. Es bueno detenerse un poco. Consideraciones finales: la investigación ha demostrado que distanciarse de las pantallas es difícil y que la presencia de profesionales de la salud, particularmente involucrados con la salud del adolescente, puede ayudarles a encontrar alternativas para usar las pantallas con reducción de las consecuencias negativas.

ABSTRACT Objective: to understand the signification of the use of screens attributed by adolescents. Methods: the current study was descriptive and exploratory, with a qualitative approach and theoretical-methodological framework of symbolic interactionism. Adolescents from a public school in Minas Gerais participated in it. Data were collected through interviews and focus groups carried out online and analyzed according to thematic analysis in the period from August to December 2020. Results: it had the participation of eight adolescents aged between 14 and 17 years, who attended high school and reported that the most used screen was the cell phone. The significations attributed to the use of screens were related to the possibility of interaction and practicality for allowing the performance of various activities. There was recognition that, in the face of excessive use, it is necessary to have a moment away from the screen. After the analysis, three categories were revealed: 1. Screen is diversity 2. Screen is interaction, 3. It is good to stop for a while. Final considerations: research has shown that distance from screens is difficult and the presence of health professionals, particularly related to adolescent health, can help them to find alternatives to use screens with reduced negative consequences.

Predicting the effects of COVID-19 related interventions in urban settings by combining activity-based modelling, agent-based simulation, and mobile phone data.

Epidemiological simulations as a method are used to better understand and predict the spreading of infectious diseases, for example of COVID-19. This paper presents an approach that combines a well-established approach from transportation modelling that uses person-centric data-driven human mobility modelling with a mechanistic infection model and a person-centric disease progression model. The model includes the consequences of different room sizes, air exchange rates, disease import, changed activity participation rates over time (coming from mobility data), masks, indoors vs. outdoors leisure activities, and of contact tracing. It is validated against the infection dynamics in Berlin (Germany). The model can be used to understand the contributions of different activity types to the infection dynamics over time. It predicts the effects of contact reductions, school closures/vacations, masks, or the effect of moving leisure activities from outdoors to indoors in fall, and is thus able to quantitatively predict the consequences of interventions. It is shown that these effects are best given as additive changes of the reproduction number R. The model also explains why contact reductions have decreasing marginal returns, i.e. the first 50% of contact reductions have considerably more effect than the second 50%. Our work shows that is is possible to build detailed epidemiological simulations from microscopic mobility models relatively quickly. They can be used to investigate mechanical aspects of the dynamics, such as the transmission from political decisions via human behavior to infections, consequences of different lockdown measures, or consequences of wearing masks in certain situations. The results can be used to inform political decisions.

CHECKEATE, aplicación tecnológica en la prevención y tratamiento de las enfermedades crónicas no transmisibles / CHECKEATE, a technological application for the prevention and treatment of chronic non-communicable diseases

La falta de cultura preventiva y un diagnóstico precoz oportuno representan dos de los factores más importantes a considerar en la prevención y tratamiento de las enfermedades crónicas no transmisibles a nivel mundial, por lo que la tecnología móvil constituye una alternativa que bien puede ser utilizada en la medicina preventiva. En este sentido, el presente artículo tuvo como objetivo validar una aplicación tecnológica que permita realizar el diagnóstico de enfermedades crónicas no transmisibles, utilizando el dispositivo móvil. Se realizó un estudio descriptivo, que utilizó la encuesta como técnica y el cuestionario como instrumento para la recolección de la información en una muestra de 60 personas mayores de 18 años, todos usuarios de la red social Facebook, quienes seguían la página https://es-la.facebook.com/DrLuisPacoraCamargo/. Los resultados obtenidos permitieron demostrar que el 57,1 por ciento de los encuestados presentaba edades comprendidas entre los 21 y 40 años de edad, de los cuales el 88,3 por ciento reportó que utilizaba internet diariamente; el 53,3 por ciento respondió que utilizaba sus dispositivos frecuentemente para comunicarse a través de las redes sociales; el 53,4 por ciento de los encuestados había descargado un aplicativo relacionado con la salud y, finalmente, el 82,8 por ciento de las personas respondió tener conocimiento del término de medicina preventiva y, que de tener información en sus dispositivos móviles, la utilizaría con frecuencia. En conclusión, el diseño e implementación de un servicio de salud a través de los dispositivos móviles, como el CHECKEATE, es viable en un mercado joven, potencialmente interesado en temas de salud preventiva(AU)

Lack of a preventive culture and of timely early diagnosis are two of the most important factors to be considered in the prevention and treatment of chronic non-communicable diseases worldwide. Mobile technology is therefore an alternative which could very well be used in preventive medicine. The purpose of the study was to validate a technological application for the diagnosis of chronic non-communicable diseases using a mobile device. A descriptive study was conducted based on the survey as technique and the questionnaire as data collection tool. The sample was 60 people aged over 18 years, all of them users of the social network Facebook, who follow the webpage https://es-la.facebook.com/DrLuisPacoraCamargo/. Results show that 57.1 percent of the respondents were aged 21-40 years; 88.3 percent reported using the Internet daily; 53.3 percent that they used their devices frequently for communication through social networks; 53.4 percent had downloaded a health-related application, and 82.8 percent were familiar with the term "preventive medicine" and would used it more frequently if they had more information on their mobile devices. In conclusion, design and implementation of a health service through mobile devices, as is the case with CHECKEATE, would be viable in a young market potentially interested in preventive health topics(AU)

Mining Google and Apple mobility data: temporal anatomy for COVID-19 social distancing.

We employ the Google and Apple mobility data to identify, quantify and classify different degrees of social distancing and characterise their imprint on the first wave of the COVID-19 pandemic in Europe and in the United States. We identify the period of enacted social distancing via Google and Apple data, independently from the political decisions. Our analysis allows us to classify different shades of social distancing measures for the first wave of the pandemic. We observe a strong decrease in the infection rate occurring two to five weeks after the onset of mobility reduction. A universal time scale emerges, after which social distancing shows its impact. We further provide an actual measure of the impact of social distancing for each region, showing that the effect amounts to a reduction by 20-40% in the infection rate in Europe and 30-70% in the US.

Effects of the use of mobile phone on postural and locomotor tasks: a scoping review.

BACKGROUND: Using a mobile phone while performing a postural and locomotor tasks is a common, daily situation. Conversing or sending messages (SMS) while walking account for a significant share of accidental injuries. Therefore, understanding the consequences of using a mobile phone on balance and walking is important, all the more so when these postural and locomotor tasks are aggravated by a disease. RESEARCH QUESTION: Our objective was to conduct a scoping review on the influence of a dual-task situation - generated by the use of mobile phone - on users' postural and/or locomotor tasks. METHODS: The literature search was conducted in English on PubMed/Medline and CINHAL databases, using keywords associated with postural and locomotor tasks and with the use of mobile phone. Study location, population, number of subjects, experimental design, types of phone use, evaluated postural-locomotor tasks and expected effects were then analyzed. RESULTS AND SIGNIFICANCE: 46 studies were included in this work, 24 of which came from North America. All studies compared postural and locomotor tasks with and without the use of a smartphone. Ten studies also compared at least 2 groups with different characteristics. Only 4 studies included pathological subjects. Various modalities were tested, and most studies focused on walking. Results show that the use of smartphones slows down movement and induces a systematic imbalance, except when listening to music. The dual task of "using the smartphone during a postural or locomotor tasks" induces systematic disturbances of balance and movement, which must be taken into account in the rehabilitation approach. Future studies will have to extend the knowledge regarding pathological situations.

Mobile phones: The effect of its presence on learning and memory.

Our aim was to examine the effect of a smartphone's presence on learning and memory among undergraduates. A total of 119 undergraduates completed a memory task and the Smartphone Addiction Scale (SAS). As predicted, those without smartphones had higher recall accuracy compared to those with smartphones. Results showed a significant negative relationship between phone conscious thought, "how often did you think about your phone", and memory recall but not for SAS and memory recall. Phone conscious thought significantly predicted memory accuracy. We found that the presence of a smartphone and high phone conscious thought affects one's memory learning and recall, indicating the negative effect of a smartphone proximity to our learning and memory.

Text message reminders for improving sun protection habits: A systematic review.

BACKGROUND: Excessive exposure to ultraviolet radiation increases the risk of skin cancer and other conditions. SMS text reminders may be a useful tool to improve sun protection habits due to its massive reach, low cost, and accessibility. OBJECTIVE: To perform a systematic review of randomized controlled trials (RCTs) that evaluated the effects of SMS text reminders in promoting sun protection habits. METHODS: We performed a systematic search in PubMed, Central Cochrane Library, and Scopus; following the PRISMA recommendations to perform systematic reviews. We included RCTs published up to December 2018, which evaluated the benefits and harms of SMS text reminders to improve sun protection habits. Random-effects meta-analyses were performed whenever possible. The certainty of the evidence was assessed for RCTs estimates using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The study protocol was registered in PROSPERO (CRD42018091661). RESULTS: Five RCTs were included in this review. When pooled, the studies found no effect of SMS text reminders in "sunburn anytime during follow-up" (two studies, risk ratio: 0.93; 95% confidence interval: 0.83-1.05). Contradictory results were obtained for sunscreen use (three RCTs) and sun protection habits (two RCTs), however, they could not be meta-analyzed because outcomes were measured differently across studies. The certainty of the evidence was very low for these three outcomes according to GRADE methodology. CONCLUSIONS: RCTs that assessed effects of SMS text reminders did not find a significant benefit on objective outcomes, such as having a sunburn, sunscreen use and composite score of sun protection habits. Since certainty of the evidence was very low, future high-quality studies are needed to reach a conclusion regarding the balance of desirable and undesirable outcomes. PROTOCOL REGISTRATION NUMBER: PROSPERO (CRD42018091661).

Link-centric analysis of variation by demographics in mobile phone communication patterns.

We present a link-centric approach to study variation in the mobile phone communication patterns of individuals. Unlike most previous research on call detail records that focused on the variation of phone usage across individual users, we examine how the calling and texting patterns obtained from call detail records vary among pairs of users and how these patterns are affected by the nature of relationships between users. To demonstrate this link-centric perspective, we extract factors that contribute to the variation in the mobile phone communication patterns and predict demographics-related quantities for pairs of users. The time of day and the channel of communication (calls or texts) are found to explain most of the variance among pairs that frequently call each other. Furthermore, we find that this variation can be used to predict the relationship between the pairs of users, as inferred from their age and gender, as well as the age of the younger user in a pair. From the classifier performance across different age and gender groups as well as the inherent class overlap suggested by the estimate of the bounds of the Bayes error, we gain insights into the similarity and differences of communication patterns across different relationships.

The Current State and Future Possibilities of Mobile Phone "Voice Analyser" Applications, in Relation to Otorhinolaryngology.

BACKGROUND: A large proportion of the population suffers from voice disorders. The use of mobile phone technology in healthcare is increasing, and this includes applications that can analyze voice. OBJECTIVE: This study aimed to review the potential for voice analyzer applications to aid the management of voice disorders. METHODS: A literature search was conducted yielding eight studies which were further analyzed. RESULTS: Seven out of the eight studies concluded that smartphone assessments were comparable to current techniques. Nevertheless there remained some common issues with using applications such as; voice parameters used; voice pathology tested; smartphone software consistency and microphone specifications. CONCLUSIONS: It is clear that further developments are required before a mobile application can be used widely in voice analysis. However, promising results have been obtained thus far, and the benefits of mobile technology in this field, particularly in voice rehabilitation, warrant further research into its widespread implementation.

Prediction of cardiorrespiratory fitness by screen time in schoolchildrens / Predição de aptidão cardiorrespiratória por meio do tempo tela em escolares

ABSTRACT The time spent in front of the screens, results in accumulations of sedentary behavior, which is related to health damages to adolescents, such as a low cardiorespiratory fitness. In this sense, this study aimed to predict cardiorespiratory fitness through screen time in schoolchildren. Cross-sectional study, as a sample composed of 2.764, of which 1.370 boys and 1.394 girls between 10 and 18 years old were the public school system of Paranavaí, Paraná, Brazil The self-report questionnaire was used to estimate screen time (ST) and cardiorespiratory fitness (CF) was estimated using the 20-meter multi-stage test, and to verify the predictive power of the screen time in relation to CF, the Roc curve was used. The results showed that screen time was considered a good predictor of cardiorespiratory fitness in boys (weekdays, weekends and all week), and in general (boys and girls) only for weekdays (Monday to Friday). In the survey, the screen time cut-off for boys on weekdays was 137 minutes (CI: 65-43), at weekends of 165 minutes (58-51) and general of 156 minutes (64-45). For the general sample (girls and boys), the cut bridge on weekdays was 142 minytes (64-44). For the girls the screen time had no predictive power (CI> 0.50) and consequently the cut-off point was not verified. Thus, it can be concluded that the screen time in boys and in general (only weekdays) was able to predict cardiorespiratory fitness and that this variable of easy application can be an important tool to predict CF in the school environment.

RESUMO O tempo gasto em frente à telas, resulta em acúmulo de comportamento sedentário, o qual está relacionado com malefícios a saúde dos adolescentes, tais como uma baixa aptidão cardiorrespiratória. Nesse sentido esse estudo teve por objetico predizer a aptidão cardiorrespiratória por meio do tempo de tela em escolares. Estudo transversal, como amostra composta por 2.764, sendo 1.370 meninos e 1.394 meninas entre 10 e 18 anos rede pública de ensino de Paranavaí, Paraná. O questionário de autorrelato foi utilizados para estimar o de tempo de tela (TL), e a aptidão cardiorrespiratória (ACR) foi estimada por meio do teste de 20 metros multiestágios. Para verificar o poder preditivo do tempo de tela em relação a ACR, a Curva Roc foi utilizada. Os resultados mostraram que o tempo de tela foi considerado um bom preditor de aptidão cardiorrespiratória em meninos (dias de semana, fins de semana e semana toda), e de modo geral (meninos e meninas) apenas para os dias de semana. Na pesquisa, o ponte de corte de tempo de tela para meninos em dias de semana foi de 137 minutos (IC: 65-43), nos fins de semana de 165 minutos (58-51) e geral de 156 minutos (64-45). Já para a amostra geral (meninas e meninos) o ponte de corte nos dias de semana foi de 142 minutos (64-44). Para as meninas o tempo de tela não teve poder preditivo (IC > 0,50) e consequentemente não foi verificado o ponto de corte. Desse modo, conclui-se que o tempo de tela em meninos e de maneira geral (apenas nos dias de semana) foi capaz de predizer a aptidão cardiorrespiratória e que essa variável de fácil aplicação pode ser um instrumento importante para predizer a ACR no ambiente escolar.

Retiring the Flip Phones: Exploring Social Media Use for Managing Public Health Incidents.

OBJECTIVE: Communication is essential during public health emergencies and incidents. This research aimed to understand current uses and challenges for public health agencies using social media during these incidents. METHODS: An exploratory, qualitative study was conducted using the structured interview matrix facilitation technique. Focus groups were held with professionals from local public health agencies across Ontario, Canada. Representation from different geographic regions was sought to capture differences in participant experience. An inductive approach to content analysis was used to identify emergent themes. RESULTS: A diverse group of public health professionals (n = 36) participated. Six themes were identified. Social media is identified as a communication tool used to expand reach of messages, to engage in dialogue with the public, and to inform the scope of potential incidents. Barriers to its use include hesitancy to adapt, lack of trust and credibility, and organizational structure and capacity constraints. Key strategies proposed to promote social media use and address barriers resulted from participant discussions and are presented. CONCLUSION: Social media use is highly variable across public health agencies in Ontario. This study identifies and provides strategies to address barriers and practice gaps related to public health agencies' use of social media during emergencies.

Appraisal of immediate and late effects of mobile phone radiations at 2100 MHz on mitotic activity and DNA integrity in root meristems of Allium cepa.

The present study evaluated the potential of 2100 MHz radiofrequency radiations to act as cytotoxic and genotoxic agent. Fresh onion (Allium cepa L.) roots were exposed to electromagnetic field radiations (EMF-r) for different durations (1 h and 4 h) and evaluated for mitotic index (MI), phase index, chromosomal aberrations, and DNA damage. DNA damage was investigated with the help of the comet assay by assessing various parameters like % head DNA (HDNA), % tail DNA (TDNA), tail moment (TM), and olive tail moment (OTM). Effects of EMF-r exposure were also compared with that of methyl methanesulfonate (MMS; 90 µM), which acted as a positive control. The post-exposure effects of EMF-r after providing the test plants with an acclimatization period of 24 h were also evaluated. Compared to the control, a significant increase in the MI and aberration percentage was recorded upon 4 h of exposure. However, no specific trend of phase index in response to exposure was detected. EMF-r exposure incited DNA damage with a significant decrease in HDNA accompanied by an increase in TDNA upon exposure of 4 h. However, TM and OTM did not change significantly upon exposure as compared to that of control. Analysis of the post-exposure effects of EMF-r did not show any significant change/recovery. Our data, thus, suggest the potential cytotoxic and genotoxic nature of 2100 MHz EMF-r. Our study bears great significance in view of the swiftly emergent EMF-r in the surrounding environment and their potential for inciting aberrations at the chromosomal level, thus posing a genetic hazard.